sqlite-utils is primarily a cli tool for sqlite operations such as enabling full text search, and executing searches, but it also has a nice python api that is exposed and pretty straightforward to use.
from sqlite_utils import Database
db = Database("database.db")
db["post"].enable_fts(["title", "message", "tags])
db["post"].search("water")
This returns a generator object that you can iterate over the row objects with.